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+;; What follows is a "manifest" equivalent to the command line you gave.
+;; You can store it in a file that you may then pass to any 'guix' command
+;; that accepts a '--manifest' (or '-m') option.
+
+(use-modules (guix transformations))
+
+(define ocaml-latest
+ (options->transformation
+ '((with-version . "ocaml=5.3.0"))))
+
+(packages->manifest
+ (list (specification->package "gcc-toolchain")
+ (ocaml-latest (specification->package "ocaml"))
+ (specification->package "opam")
+ (specification->package "node")))